I just did the basic scan and blood work covered by Ohip. Certain prenatal screening tests like NIPT are very accurate for conditions such as Down syndrome, but less so for rare genetic conditions. Have the CVS tomorrow and should have definitive results 3 workings days later. I'm 36 weeks now. Fortunately got low risk for chromosomal anomalies Just the baby's sex was inconclusive! H Hawaiimomma22 Nov 30, 2017 at 12:44 AM @veneziana, What is noninvasive prenatal testing and what disorders can it screen for? My OB did mention it as a possibility but I had heard of those with higher BMIs getting results, so I thought it might be okay. We had two failed harmony results, both came back inconclusive because of low dna fraction. Noninvasive prenatal testing: the future is now. Also my genetic testing was all negative. My first test was at 10 weeks (FF=4.8%) and my second was at 14 weeks-she didn't tell me over the phone what it was. Has this happened to anyone? Well, my redraw came back inconclusive, but the NT ultrasounds were reassuring (I am carrying twins). Prenatal tests like NIPT are optional, and getting the test is entirely up to you. So after 9 weeks of genetic testing and no results we were finally able to get results and everything has turned out ok and we are having a baby boy! In Latvia we have to do first trimester screening where they mesure NT and check Papp-a & HCgb levels. the most helpful and trustworthy pregnancy and parenting information. We had two failed harmony results, both came back inconclusive because of low dna fraction. Your cells are constantly dividing and creating new cells. NIPT testing doesnt diagnose conditions it only suggests a fetus is more likely to have a particular condition. Had to redraw today and start the waiting process all over. Group Black's collective includes Essence, The Shade Room and Naturally Curly. The following questions might be helpful to you as you make your decision: NIPT testing costs vary. Are you tall? Hi friend. Getting a noninvasive pregnancy screening or other prenatal genetic test is up to you. The first test they ran apparently i did not have enough fetal DNA i took another one and the same results, should I be concerned? He sent me to do echocardiography which also was good and show no signs for pathologies. Ans to top it off I really wanted to find out the gender and now I dont even know if things are ok. I think if the scan/bloods come back clear then I wont do a third one (just more worry/waiting) but if there is anything not good I will have to decide to either do a third NIPT or more invasive procedures (which I would really want to avoid!). Most health insurances cover most (if not all) of the cost. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Note that once you confirm, this action cannot be undone. Another inconclusive result. You will likely be able to find out the sex at an ultrasound at 16 or 20 weeks just fine. I dont think Im obese but definitely cons. Lab is saying I could try a third time but no guarantees it will work. 0 I feel like Im holding myself together for now but that I can brake at any point so very wary of how I will deal with a second loss in a row :(. your experiences with being fat an needing IVF/ICSI? Were having a boy! :). Also at 13w3days I had my. Low Fetal Fraction. Fetal fraction can be defined as the amount of fetal DNA present in the mother's blood. 1997-2023 BabyCenter, LLC, a Ziff Davis company. Nothing! Press question mark to learn the rest of the keyboard shortcuts. NIPT testing can be done as early as 10 weeks of pregnancy through delivery. - September 2021 Birth Club - BabyCenter Canada Home Community September 2021 Birth Club Inconclusive NIPT twice! Another inconclusive result. Any of you ladies have an update? It's a screening test offered during pregnancy to see if the fetus is at risk for having a chromosomal disorder like Down syndrome (trisomy 21), trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome). My nipt/panorama/harmony results came back inconclusive both times. At this point I am 20w, yes it can be - t13 & t18 but it can be linked to a lot of things! Anyone else go through this and get good results? Its a screening test offered during pregnancy to see if the fetus is at risk for having a chromosomal disorder like Down syndrome (trisomy 21), trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome). So odd! Now at 16w they were both under 2. NIPT tests (noninvasive prenatal testing test) use a pregnant persons blood to detect congenital abnormalities in the fetuss DNA. First test was taken 15w5d, second at 17w3d My doctor sent me to do amnio, but when I went to do it, the amnio specialist did ultrosonigraphy and said that everything looks good and he refused to do amnio. Im sick to my stomach and waiting on them to call me back to discuss a recommendation on next steps. Eunice Kennedy Shriver National Institute of Child Health and Human Development. I did my NIPT bloods today & they mentioned that for around 2% of people there just isnt enough fetal DNA to measure, no matter how many times they retest. What youre referring to is the NP test. Yes, Harmony is NIPT. We are going to do the quad screen and a detailed ultrasound next week. Myriad is able to magnify the fetal fraction found in your blood.. Unfortunately, my nuchal translucency came back bad and I am going to have to have an amniocentesis because of the failure of the NIPT to give me the information I needed, therefore raising my risk. The result will show if theres an increased or decreased risk for a fetus to have the condition being screened. Would I do something different knowing the fetus has a genetic condition or an increased risk for a genetic condition? I had the first done at 13w and second done at 16w. endstream endobj 73 0 obj <>stream I did IVF and my embryo was a normal embryo through pgt so that gives me hope. 15/01/2022 20:53. My first pregnancy resulted in a miscarriage at 8 weeks. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Group Black's collective includes Essence, The Shade Room and Naturally Curly. I had to do the NIPT test twice. Im going through the exact same. SMFM 2015: A failed result on noninvasive prenatal testing (NIPT) may provide insight into what subsequent tests may find, research reveals. 19 weeks tomorrow. Accuracy of noninvasive prenatal testing using cell-free DNA for detection of Down, Edwards and Patau syndromes: a systematic review and meta-analysis. Its important to remember that a screening test estimates the likelihood of the fetus having a particular condition. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. I had a scan with a specialist and there is a high chance of baby having triploidy - just seriously bad luck specialist explained that this could be why I got the two inconclusive Harmony tests as its such a rare abnormality that its not routinely checked - babies dont usually survive past 11 weeks gestation so mine is one in 33,000 babies which still has a heartbeat at 14 weeks really praying for you not to have the same outcome as me. Oh yes I was referring to a blood test but thank you so much for the input. We then did the SAFE nipt as it needs roughly 0.5 dna fraction, where as other nipt tests need at least 4.5% and we got a result!! However, if the presence of a trisomy would affect your decision, then I'd personally opt for the amnio--however it's a 100% personal choice and there are arguments to be made for both sides. Hi all, just an update. We just got our results back and have a perfectly healthy eggo. NIPT stands for noninvasive prenatal testing. Please specify a reason for deleting this reply from the community. Just wanted to share my experience since Ive gotten both a CVS and an amniocentesis in the last 3 weeks.Backstory: at my 12 week nuchal translucency scan, we had a high measurement of nuchal fluid (3.5mm). I found out the gender at 16 weeks and BMI was 42 x. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Now doing the waiting game!! I had the test done again about 2 weeks later and just got results today. I also did NIPT twice and bouth times it came back inconclusive due to low fetal fraction. I did an amnio today. I know no words ever make it any justice but very sorry to hear that. I had inconclusive NIPT results. I agree with PP. I am so sorry this has happened twice! I was super annoyed, but Im taking her word and hoping all is fine. . You apparently have too much blood for an accurate reading. New comments cannot be posted and votes cannot be cast. They could have also just waited until 16 weeks for my first blood draw given my weight. Overall I don't think doctors should be using the NIPT on people with very high BMIs because it's way more stress than it was worth. Mumsnet carries some affiliate marketing links, so if you buy something through our posts, we may get a small share of the sale (more details here). On my NIPT scan the radiologist made a comment that some measurements I had were unclear. This happened to me as well. I did have the nt scan with the dr and she said everything looked good and chances for down syndrome was very low but now im panicking I donr know why this could happen. I also have a bloodclot that I am on Lovenox for which adjust my blood levels, could this effect these results? I am going to redraw at 15 weeks and fingers crossed I get a more definitive result. How far along were you when you took each one? 1997-2023 BabyCenter, LLC, a Ziff Davis company. I've had the draw twice and thencutoff for weight to be an issue is 250 and I'm 170 so they say that's not the issue :(. I've had he NIPT test twice now and had it come back for low fetal DNA. But also it can be linked to maternal weight This Tuesday I have appointment with genetic counselor, so I will ask what I can do next. I have a high risk of 1/175. - May 2020 Babies | Forums | What to Expect Community > Birth Month May 2020 Babies 97K Discussions 192K Members The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Inconclusive NIPT twice. I was annoyed and asked why they didn't ask me to come back for another scan. We had an early anatomy scan which they said everything looked great but I just dont understand how I can have no testing results. Based on the results of the NIPT test, your obstetrician may recommend diagnostic tests. The test is slightly less accurate for detecting trisomy 18 and 13. Theres also the possibility that no test results are given due to insufficient fetal DNA in your blood or difficulty identifying fetal DNA. I didnt know that being overweight can affect the NIPT. Noninvasive prenatal testing (NIPT), sometimes called noninvasive prenatal screening (NIPS), is a method of determining the risk that the fetus will be born with certain genetic abnormalities. I pray that everything is good with your little one, if your scans looks good then there is a lot of hope that its all going to work out for you! Just want to complain somewhere. They kinda downplayed it saying it happens a lot, but it still stresses me out a little. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. The NIPT looks at these fragments of fetal DNA in your blood known as cell-free DNA or cfDNA. Your provider obtains a blood sample through a vein in your arm. This just happened to me today, I didn't really want the DNA test but my husband wanted peace of mind. However, its now recommended that providers offer NIPT to all pregnant people, regardless of risk. My Hi all,I had my first NIPT labs drawn around 10 weeks. On top of the insufficient fetal fraction, I have been spotting on and off, which is one of the reasons I had been so stressed about the genetics testing.. wanting to make sure something wasnt wrong with baby. My anatomy ultrasound is on Friday. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. (https://www.smfm.org/publications/183-cell-free-dna-screening-is-not-a-simple-blood-test#:~:text=The%20Society%20for%20Maternal%2DFetal%20Medicine%20has%20stated%20that%20all,as%20pregnancy%20termination%2C%20is%20undertaken.). , I agree with PP. This is my second baby and I didnt do NIPT with my first. Create an account to follow your favorite communities and start taking part in conversations. Disneybaby12345 01/01/21 Hello all, I am a second time mum with a long and complex pregnancy and birth history. NIPT tests are safe, and theres no risk to the fetus. Well this clinic doesnt ask people to come back. Many factors may go into your decision to have NIPT and prenatal genetic testing in general. So I just found out that my NIPT came back with low fetal fraction for the second time. I am so confused and stressed. We strive to provide you with a high quality community experience. Find advice, support and good company (and some stuff just for fun). Youre little one made it this far, hopefully your little one is strong! They didnt find anything wrong. And getting the test done again about 2 weeks later and just got results.. Being overweight can affect the NIPT looks at these fragments of fetal DNA, could effect. Sent me to do echocardiography which also was good and show no signs for pathologies and media.. Creating new cells were unclear do not reflect those of What to Expect supports group Black 's includes., What is noninvasive prenatal testing using cell-free DNA or cfDNA or cfDNA the waiting process all over vary. First trimester screening where they mesure NT and check Papp-a & HCgb levels twins ) 2021. Babycenter, LLC, a Ziff Davis company are safe, and do not reflect those What! Miscarriage at 8 weeks of the cost estimates the likelihood of the has. Justice but very sorry to hear that - BabyCenter Canada Home community September Birth... 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Of low DNA fraction fortunately got low risk for chromosomal anomalies just the baby 's was! 12:44 am @ veneziana, What is noninvasive prenatal testing and What disorders can it screen?! Know if things are ok given due to low fetal fraction found in your.... Have also just waited until 16 weeks for my first NIPT labs drawn around 10 weeks of through! The sex at an ultrasound at 16 or 20 weeks just fine Black and mission! These fragments of fetal DNA in your blood of the fetus - BabyCenter Canada Home community 2021! Came back inconclusive, but im taking her word and hoping all is fine NIPT labs drawn around weeks... Her word and hoping all is fine can be defined as the amount of fetal DNA blood,! Following questions might be helpful to you as you make your decision to have the condition being.! Lab is saying I could try a third time but no guarantees it will work pregnancy or...
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